Paulette Chandler '88

Assistant Professor of Medicine, Harvard Medical School
Associate Epidemiologist, Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA
Primary Care Physician, Brigham and Women’s Hospital, Boston, MA
  • M.D., Duke University Medical School
  • BSE, Electrical Engineering, Princeton University

Paulette Chandler, M.D., MPH, is an assistant professor of medicine at Harvard Medical School, associate epidemiologist in the Division of Preventive Medicine and a primary care physician at Brigham and Women’s Hospital in Boston, MA. She completed her BSE in electrical engineering and computer science in 1988 at Princeton University and a doctorate in medicine at Duke University Medical School in 1993. After finishing an internal medicine residency at Brigham and Women’s Hospital, she completed a community health fellowship and master of public health in clinical effectiveness at Harvard T. H. Chan School of Public Health.

Dr. Chandler’s research focuses on understanding the connections between novel biomarkers generated through the “-omics” technology and nutrition for cancer prevention. Her American Cancer Society Mentored Research Scholar Grant in Applied and Clinical Science focused on uncovering links between nutrition and colorectal cancer risk by using metabolomics to measure a wide profile of circulating small-molecule metabolites to comprehensively evaluate metabolic pathways linked to risk factors that may be more prevalent in those who eat a Western versus Mediterranean diet, with the goal of prompting new therapies and dietary recommendations.

As a co-investigator for All of Us New England, Dr. Chandler worked on two All of Us Demonstration projects for alpha testing of the All of Us Research Workbench. As part of the All of Us New England Engagement and Communications Team, she is a statistical analyst for pilot studies for improving survey response rates and retention. The All of Us Research Program is a historic effort to gather data from one million or more people living in the United States to accelerate research and improve delivery of personalized health care. She is also a co-investigator for Electronic Medical Records and Genomics network, Phase IV (eMERGE IV) project that focuses on using the electronic health record to deliver genomic risk assessment based on polygenic risk scores for a variety of diseases in the clinical setting.  Her goal is to use the electronic health record to deliver precision care based on biomarkers.

Dr. Chandler’s clinical interests include nutrition, cancer and diabetes prevention, and women’s health. She is actively involved with several randomized clinical trials and observational studies. She serves on the Cancer Endpoints Committee of the VITAminD and OmegA-3 Trial (VITAL) and COcoa Supplement and Multivitamin Outcomes Study (COSMOS) and serves as a Medical/Safety Officer for the COSMOS and the Kronos Early Estrogen Prevention Study (KEEPS) studies. She serves as lead for community engagement and education for COVID-19 vaccine trials at Brigham and Women’s Hospital.