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The emerging field of bioelectronic medicine seeks methods for continuous real-time monitoring of biomarkers in the body to better understand health status and disease prognosis and for deciphering and modulating electrophysiological activity in the body to attain therapeutic effects at target organs. Existing technologies for interfacing with the internal body parts rely on wired connections or batteries, creating problems for chronic use, while emerging wireless systems usually lack the size scalability necessary to safely interface with targeted organs/tissues/nerves deep in the body. In this talk, I will first discuss how to design and implement safe, scalable implantable wireless systems based on tiny, sub-millimeter or millimeter-sized, electronic implants that can address all the challenges above. Next, I will present the first minimally invasive, deep-tissue oxygen monitoring system that comprises a millimeter-sized, wireless, implantable luminescence oxygen sensor and an external transceiver for power and bi-directional data transfer; this system reports continuous real-time data from centimeter-scale depths in sheep. I will then demonstrate a new packaging approach that enables the design of efficient wireless power and data link for miniaturized implants, which provides a path towards the extreme miniaturization of implants to sub-millimeter scales. Finally, I will conclude this talk with my future directions in the development of ultra-miniature implantable wireless systems that can open the door to novel diagnostics and therapeutics.
Soner Sonmezoglu is a postdoctoral scholar in the Department of Electrical Engineering and Computer Sciences at the University of California, Berkeley. He received his Ph.D. degree from the University of California, Davis in 2017 and B.S. and M.S. degrees with a minor degree in Solid-State Physics from the Middle East Technical University, Turkey in 2010 and 2012, respectively. He spent the summer 2015 at Kilby Labs, Texas Instruments, Inc. as a design engineering intern. His research interests are broadly in integrated sensors, devices, and systems for health monitoring, diagnostic and therapeutic applications. Soner’s work has been published in top-tier Nature (in press), AIP, and IEEE journals and conference proceedings.